What role do B3 receptors play in micturition?

B3 receptors, also known as beta-3 adrenergic receptors, play a crucial role in the regulation of the bladder by promoting relaxation of the detrusor muscle during the filling phase of micturition. When these receptors are activated, they facilitate bladder capacity by allowing the detrusor muscle to remain relaxed, which is essential for accommodating increasing volumes of urine without triggering involuntary contractions.

This relaxation is a key aspect of bladder physiology, as it helps maintain continence and is particularly important for individuals who may have overactive bladder or other disorders of micturition where involuntary contractions lead to urgency and increased frequency of urination. Understanding the action of B3 receptors is vital for developing treatments that target these pathways to improve bladder function and quality of life for patients experiencing micturition disorders.